No matter what programs you are running, backups are critical. Generally, the safest backups are those made directly by the backup program of the software and then those backups should be backed up offsite for extra protection.
Backups from the software program are more likely to be complete and accurate as they can take account of whether someone is logged in to the program.
But what do you do when your backup doesn’t work? If the program is QuickBooks, William Murphy has provided great insight into causes and fixes when it comes to QuickBooks backup. You can ready his complete article at Insightful Accountant – QuickBooks backup.